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Creon 10,000 IU Capsules 100's monster-high Monster High family doll packsCreon capsules is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes. This condition is called exocrine pancreatic insufficiency (EPI) and may be due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.